- How is CMT passed down?
- How can a child inherit a disease if neither parent appears to have it?
- Is CMT a disability?
- Does CMT make tired?
- How do you get CMT?
- Can CMT skip a generation?
- Is CMT more common in males or females?
- What is Charcot Marie Tooth type 2?
- Does CMT cause leg cramps?
- Is CMT related to MS?
- Does CMT affect memory?
- Can CMT affect your eyes?
- What does a Charcot foot look like?
- Can CMT be passed from father to son?
- At what age does CMT present?
- Does CMT affect your brain?
- Can you build muscle with CMT?
How is CMT passed down?
All types of CMT are inherited from the parents of the affected individual, and can be passed on to their children.
There are different types of CMT caused by mutations or errors in different genes.
Depending on the type, CMT is inherited in autosomal dominant, autosomal recessive, or X-linked pattern..
How can a child inherit a disease if neither parent appears to have it?
Dominant inheritance means an abnormal gene from one parent can cause disease. This happens even when the matching gene from the other parent is normal. The abnormal gene dominates. This disease can also occur as a new condition in a child when neither parent has the abnormal gene.
Is CMT a disability?
Medically Qualifying Under A Disability Listing: CMT is a form of peripheral neuropathy, meaning it affects the nerves and muscles in the arms, legs, hands, and feet. The Social Security Administration (SSA) has a standard disability listing for this type of neurological disorder.
Does CMT make tired?
Fatigue is a common symptom in CMT. A study, published in the Journal of Neurology in 2010 and based on questionnaire given patients and an age- and sex-matched control group, reported that fatigue levels were significantly higher in people with CMT. Fatigue in CMT can be due to a number of reasons.
How do you get CMT?
CMT is caused by mutations in genes that support or produce proteins involved in the structure and function of either the peripheral nerve axon or the myelin sheath. More than 40 genes have been identified in CMT, with each gene linked to one or more types of the disease.
Can CMT skip a generation?
CMT does not skip generations genetically. For people with autosomal dominant and X-linked conditions, a person will either have the condition or not. If a parent has CMT that has been genetically confirmed, a child can be tested when that child is at least 18 years of age and with appropriate genetic counseling.
Is CMT more common in males or females?
The condition affects an equal number of males and females. CMT hereditary neuropathy is the most common inherited neurological disorder affecting more than 250,000 Americans. Since this condition is frequently undiagnosed, misdiagnosed or diagnosed very late in life, the true number of affected persons may be higher.
What is Charcot Marie Tooth type 2?
Charcot-Marie-Tooth disease type 2 (CMT2) is a type of CMT with genetic defects that disrupt the structure and function of the axons of the peripheral nerves. So, CMT2 often is referred to as “axonal CMT.” CMT2 is less common than CMT1 and accounts for about one-third of all dominant CMT cases.
Does CMT cause leg cramps?
1-4 Muscle cramps are frequent in CMT, affecting up to 85% of patients with some subtypes of CMT. These cramps impact quality of life and have been identified as an important therapeutic target for clinical trials in CMT. 1-4 There is no FDA approved treatment for muscle cramps.
Is CMT related to MS?
CMT, Multiple Sclerosis (MS) and Muscular Dystrophy (MD)are three completely separate and distinct diseases.
Does CMT affect memory?
The most common cause of CMT is the duplication of a region on the short arm of chromosome 17, which includes the gene PMP22. We report a thirty-seven-year-old man with CMT disease having sleep, memory and attention disorders characterized by brief retrograde amnesia at early age.
Can CMT affect your eyes?
CMT Type 6 involves development of optic atrophy with loss of vision or blindness, muscle atrophy and weakness, loss of sensation, and balance and gait difficulties. Depending on the genetic cause of the CMT Type 6, there may be other symptoms including delayed learning.
What does a Charcot foot look like?
As the disorder progresses, the joints collapse and the foot takes on an abnormal shape, such as a rocker-bottom appearance. Charcot foot is a serious condition that can lead to severe deformity, disability and even amputation.
Can CMT be passed from father to son?
Many parents have no idea they are carriers of a disease until they have a child with the disease. CMT also can occur when a new mutation occurs during the child’s conception. These are called spontaneous mutations, and after they occur, they can be passed on to the next generation.
At what age does CMT present?
The age of onset of CMT can vary anywhere from young childhood to the 50s or 60s. Symptoms typically begin by the age of 20.
Does CMT affect your brain?
Unlike other neurological disorders, CMT usually isn’t life-threatening, and it almost never affects the brain. It causes damage to the peripheral nerves — tracts of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.
Can you build muscle with CMT?
You cannot build up muscles that are heavily affected by CMT because the nerve-muscle connection is not working well there. Still, you can strengthen those muscles that are not affected by CMT.